This is a sketch of my current setup. I usually play a Paul Reed Smith with Dragon pickups, which gives me a heavier sound, but sometimes I play a Fender Squire Strat with a Seymour Duncan JB Jr. pickup in the bridge when I want a not-so-heavy sound. I go from my guitar to a Boss CE-5 Chorus Ensemble, run usually with the both high and low filters off, rate about 1/4 on, and level and depth maxed out. This setting tightens and widens the sound (for clean or distortion) and allows me to use pinch harmonics. I go then into the High Sensitivity input of the 5150 head, into a cab with Celestion and Peavey speakers. The clean channel pre-gain is at 2 1/2 to 3 (slightly overdriven) and the lead pre-gain is on 3 to 3 and 1/2. Bass is 6 1/2 to 7, mid at 4, treble at 6 for the Fender, 8 for the PRS, resonance at 2 to 3, and presence at 6 to 8, depending on the guitar. I also use the Crunch switch on the Rhythm channel when I
want a naturally distorted, not as saturated, sound. When the amp
is cranked with the Crunch switch in, to me it's a sound from Heaven.